Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Dai Y, Pratte M. Dai Y, & Pratte M Dai, Yuchen, and Michael Pratte. Trends in morbidity and mortality of extremely preterm infants in the United States. 2 Minute Medicine, 24 January 2022. McGraw Hill, 2022. AccessMedicine. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=580012§ionid=263917435APA Citation Dai Y, Pratte M. Dai Y, & Pratte M Dai, Yuchen, and Michael Pratte. (2022). Trends in morbidity and mortality of extremely preterm infants in the united states. (2022). 2 minute medicine. McGraw Hill. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=580012§ionid=263917435.MLA Citation Dai Y, Pratte M. Dai Y, & Pratte M Dai, Yuchen, and Michael Pratte. "Trends in morbidity and mortality of extremely preterm infants in the United States." 2 Minute Medicine McGraw Hill, 2022, https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=580012§ionid=263917435. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Autosuggest Results Trends in morbidity and mortality of extremely preterm infants in the United States by Yuchen Dai, Michael Pratte Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. + 1. Among extremely preterm infants born at 22-28 weeks’ gestational age in 2013-2018 in the United States, 78.3% of infants survived to discharge, a significant improvement from 76.0% in 2008-2012. + 2. Among infants born at less than 27 weeks’ gestational age, rehospitalization and severe neurodevelopmental impairment were common at 2-year follow-up. + Evidence Rating Level: 2 (Good) Study Rundown: + +Although modern practices and treatment guidelines have greatly reduced mortality and morbidity in extremely preterm infants, on-going review of neonatal outcomes is needed to develop care strategies, guide interventions, and ultimately improve survival and quality of life outcomes. This observational study evaluated mortality, in-hospital morbidities, care practices, and neurodevelopmental and functional outcomes at 22-26 months’ corrected age for extremely preterm infants born in the United States between 2013 and 2018. The main outcomes were survival and in-hospital morbidities including necrotizing enterocolitis, infection, intracranial hemorrhage, retinopathy of prematurity, and bronchopulmonary dysplasia. At 2-year follow-up, infants were assessed for health and functional outcomes including neurodevelopment, cerebral palsy, vision, hearing, rehospitalizations, and need for assistive devices. Data was compared to a similar cohort of preterm infants from 2008-2012. Among 10877 extremely preterm infants born in 2013-2018, 78.3% of infants survived to discharge, a significant improvement from 76.0% in 2008-2012. Among infants who survived to their 2-year follow-up, 49.9% had been rehospitalized and severe neurodevelopmental impairment occurred in 21.2%. A limitation of this study was that although the Neonatal Research Network cohort included a large and diverse sample size, it is an academic hospital-based database and thus, does not represent the sociodemographics of the entire US preterm population. + Click to read the study in JAMA + Click to read an accompanying editorial in JAMA + Relevant Reading: Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012 In-Depth [prospective cohort]: + +This study included 10877 infants (49.0% female) born at 22-28 weeks’ gestational age between January 2013 and December 2018, including 2566 infants who completed follow-up at 2 years’ corrected age. Data was collected from a registry for extremely preterm infants born at 19 US centers and compared to a similar cohort of infants from 2008-2012. Overall, 78.3% of infants survived to discharge (from 76.0% in 2008-2012; adjusted difference, 2.0%; 95%CI, 1.0%-2.9%). The incidence of all in-hospital morbidities were more likely in extremely preterm infants, including necrotizing enterocolitis (8.9%), early-onset infection (2.4%), late-onset infection (19.9%), intracranial hemorrhage (14.3%), retinopathy of prematurity (12.8%), and bronchopulmonary dysplasia (8.0%). Among 2566 infants evaluated at 2-year follow-up, 8.4% had cerebral palsy, 1.5% had bilateral blindness, 2.5% required hearing aids or cochlear implants, 49.9% had been rehospitalized, and 15.4% required mobility aids or other supportive devices. Lastly, in 2458 fully evaluated infants, 48.7% had no or mild neurodevelopmental impairment, 29.3% had moderate neurodevelopmental impairment, and 21.2% had severe neurodevelopmental impairment. +©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.