Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Mistry N, Guo T. Mistry N, & Guo T Mistry, Neel, and Teddy Guo. Balancing vaccination rates with the lifting of lockdown restrictions may mitigate COVID-19 transmissibility. 2 Minute Medicine, 18 January 2022. McGraw Hill, 2022. AccessMedicine. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=579752§ionid=263667791APA Citation Mistry N, Guo T. Mistry N, & Guo T Mistry, Neel, and Teddy Guo. (2022). Balancing vaccination rates with the lifting of lockdown restrictions may mitigate covid-19 transmissibility. (2022). 2 minute medicine. McGraw Hill. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=579752§ionid=263667791.MLA Citation Mistry N, Guo T. Mistry N, & Guo T Mistry, Neel, and Teddy Guo. "Balancing vaccination rates with the lifting of lockdown restrictions may mitigate COVID-19 transmissibility." 2 Minute Medicine McGraw Hill, 2022, https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=579752§ionid=263667791. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Autosuggest Results Balancing vaccination rates with the lifting of lockdown restrictions may mitigate COVID-19 transmissibility by Neel Mistry, Teddy Guo Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. According to the mathematical model, a one-month delay in lifting all restrictions may have decreased peak hospital admissions by three-fold. +2. Increased laxity in reopening can help to negate the negative impact of the delta variant. +Evidence Rating Level: 2 (Good) Study Rundown: + +With the increase of vaccine availability in early 2021, the UK government designed a four-step out-of-lockdown policy for stepwise lifting of non-pharmaceutical interventions (NPIs) in March 2021. Sequentially, this included school reopening, outdoor hospitality and non-essential retail opening, indoor hospitality reopening, and lifting of all remaining restrictions. However, the emergence of the delta variant a few months after resulted in a rapid increase in COVID-19 cases. This mathematical modelling study aimed to assess the impact of the UK government’s four-step framework on easing lockdown restrictions in England, UK. Outcomes of interest included overall mortality and total number of hospital admissions. According to study results, there was significant uncertainty in determining the trajectory of the pandemic, given vaccine hesitancy and transmissibility of the delta variant. However, the stepwise reopening framework in tandem with increasing vaccination rates may have mitigated a substantial number of COVID-19 cases. In particular, a one-month delay of step four in the reopening policy, from June to July 2020, may have attenuated peak daily cases by three-fold. These findings suggest relaxation of lockdown restrictions should be balanced with rates of vaccine uptake, vaccine effectiveness, and potential variants of concern. +Click to read the study in The Lancet +Relevant Reading: Simulation-Based Estimation of SARS-CoV-2 Infections Associated With School Closures and Community-Based Nonpharmaceutical Interventions in Ontario, Canada In-depth [retrospective cohort]: + +This mathematical model used factors such as hospital admissions, hospital occupancy, seroprevalence data, and population-level PCR testing to determine the trajectory of COVID-19 in England, according to various time frames of NPI relaxation. The first step of lifting restrictions began on March 8, 2021. The delta variant emerged in UK in April 2021, having a transmission advantage of 76% (95% credible interval [95% CrI] 69-83). Accordingly, step four of the framework, which was initially scheduled for June 20, 2021, was delayed by almost a month to July 19, 2021. The model predicted that lifting all remaining restrictions in June may have resulted in 3900 (95% CrI 1500-5700) peak daily hospital admissions. Instead, a delay in reopening reduced peak daily hospital admissions by three-fold to 1400 (95% CrI 700-1700). The current model was affected by transmission of delta variant and vaccine effectiveness. Overall, the proportion of active COVID-19 cases can be dramatically reduced by appropriate timing of NPI relaxation and continued vaccine rollout. +©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.