Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Willis J, Guo T. Willis J, & Guo T Willis, Jessie, and Teddy Guo. Third dose of BNT162b2 COVID-19 vaccine effective at decreasing risk of hospitalization. 2 Minute Medicine, 16 December 2021. McGraw Hill, 2021. AccessMedicine. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=578574§ionid=263020316APA Citation Willis J, Guo T. Willis J, & Guo T Willis, Jessie, and Teddy Guo. (2021). Third dose of bnt162b2 covid-19 vaccine effective at decreasing risk of hospitalization. (2021). 2 minute medicine. McGraw Hill. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=578574§ionid=263020316.MLA Citation Willis J, Guo T. Willis J, & Guo T Willis, Jessie, and Teddy Guo. "Third dose of BNT162b2 COVID-19 vaccine effective at decreasing risk of hospitalization." 2 Minute Medicine McGraw Hill, 2021, https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=578574§ionid=263020316. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Autosuggest Results Third dose of BNT162b2 COVID-19 vaccine effective at decreasing risk of hospitalization by Jessie Willis, Teddy Guo Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Compared to two doses of the BNT162b2 vaccine, a third booster dose was estimated to be 93% effective against admission to hospital due to COVID-19 infection. +2. A third dose was also associated less severe disease and lower COVID-19 related mortality. +Evidence Rating Level: 2 (Good) Study Rundown: + +Despite a rigorous vaccination campaign in Israel, the country is still reporting vaccine “breakthrough” cases of COVID-19. Israel, which has already rolled out many third doses of BNT162b2 mRNA vaccine, may be used as a pseudo-trial population to evaluate third dose vaccine effectiveness. This was the goal of this study, which compared individuals who had received a third dose at least 5 months after their second dose. Using demographically matched controls with only two doses, effectiveness of preventing hospitalization, severe disease and death was measured. This study found that a third dose of the BNT162b2 was highly effective at preventing hospitalization compared to two doses. Three doses were also more effective at preventing severe disease and death from COVID-19. Efficacy from a third dose was most pronounced in individuals over the age of 40. Limitations included lack of individual data for patients under 40. Nonetheless, this study provides key information which will help inform national vaccination strategies moving forward. +Click to read the study in the Lancet +Click to read an accompanying editorial in the Lancet +Relevant Reading: Vaccine breakthrough infections: the possibility of getting COVID-19 after getting vaccinated In-Depth [retrospective cohort]: + +This retrospective study utilized the large number of vaccinated Israeli population to investigate the effectiveness of a third dose of the mRNA BNT162b2 (Pfizer) vaccine. The eligible population included individuals who had received two doses at least 5 months prior to their third dose. A matched control group was also included which exactly matched the treatment group by age, sex, place of residence, and risk factors for severe COVID-19 infection, but had only received two doses total. There were 728 321 matched pairs, 51% female and a median age of 52 years. 198 476 individuals were matched to themselves before and after third dose. Outcomes included risk of admission to hospital, severe disease, and death from COVID-19 infection. Outcomes were recorded 7 days after third dosage was received and continued for a median follow-up of 13 days. +Compared to two doses, a third dose conferred an effectiveness of 93% against hospital admission, 92% against severe disease and 81% against death from COVID-19. Similar effectiveness difference was seen in comparing males and females. For age group, greater significance in effectiveness difference was seen in age groups 40-69 (92%) and >70 (93%), than compared to ages 16-39 (70%). +©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.