Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. Plasma sulfar amino acids and risk of cerebrovascular diseases. 2 Minute Medicine, 1 January 2021. McGraw-Hill, 2021. AccessMedicine. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=555115§ionid=253087178APA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. (2021). Plasma sulfar amino acids and risk of cerebrovascular diseases. (2021). 2 minute medicine. McGraw-Hill. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=555115§ionid=253087178.MLA Citation Dougherty B, Chan A. Dougherty B, & Chan A Dougherty, Brian, and Alex Chan. "Plasma sulfar amino acids and risk of cerebrovascular diseases." 2 Minute Medicine McGraw-Hill, 2021, https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=555115§ionid=253087178. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Plasma sulfar amino acids and risk of cerebrovascular diseases by Brian Dougherty, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Plasma concentration of homocysteine was found to not be associated with incident stroke in a case-control, nested study. +2. Both methionine concentration and methionine to homocysteine ratio were associated with a lower risk of incident stoke. +Evidence Level Rating: 2 (Good) +Stroke is a leading cause of morbidity and mortality worldwide, and homocysteine, formed from the metabolism of methionine, has been recognized as the major sulfur-containing amino acid linked to cardiovascular disease, including stroke, though the pathogenesis is somewhat unclear. Furthermore, due to the relationship between homocysteine and other sulfur-containing compounds, there is a risk of confounding variables. This nested case-control study of the EPIC (European Prospective Investigation Into Cancer and Nutrition)-Norfolk study examined the association of plasma concentration of individual sulfur-containing compounds as well as the ratio of methionine to homocysteine – which represents the activity of one-carbon metabolism – with the incidence of stroke. From the original EPIC-Norfolk study (n = 25,639), 480 cerebrovascular disease cases (mean [SD] age = 67.4 [7.3] years, 52.3% female) and 480 matched controls (mean [SD] age = 67.2 [7.3] years, 52.3% female) were evaluated. It was found that higher plasma concentrations of homocysteine were significantly associated with incident stroke; this associated, though, was attenuated after adjustment. In contrast, higher plasma concentrations of methionine and a higher methionine to homocysteine ratio were both associated with a lower risk of incident stroke, with odds ratios per 1 SD of 0.83 (95% CI 0.72 to 0.96) and 0.82 (95% CI 0.71 to 0.95), respectively. This association persisted after adjusting for homocysteine and other potential variables like lipid levels and blood pressure. Other sulfur-containing compounds like cystathionine, cysteine, glutathione, and taurine were not associated with a risk of stroke. In all, though the plasma concentration of homocysteine was not found to be associated with incident stroke, there may be a potential role for methionine in the prevention of cerebrovascular disease. +Click to read the study in JAHA +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.