Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. Mood homeostasis associated with mean mood and depression. 2 Minute Medicine, 14 May 2020. McGraw-Hill, 2020. AccessMedicine. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=550133§ionid=247015868APA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. (2020). Mood homeostasis associated with mean mood and depression. (2020). 2 minute medicine. McGraw-Hill. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=550133§ionid=247015868.MLA Citation Lennon J, Shah R. Lennon J, & Shah R Lennon, Jack, and Ravi Shah. "Mood homeostasis associated with mean mood and depression." 2 Minute Medicine McGraw-Hill, 2020, https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=550133§ionid=247015868. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Mood homeostasis associated with mean mood and depression by Jack Lennon, Ravi Shah Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Mood homeostasis, or the preferential ability to engage in adequate mood-modifying behaviors, is associated with mean mood and history of depression. +2. Individuals with low mean mood had significantly lower mood homeostasis scores than those with higher mean moods. This relationship was also found among those who had a history of depression compared to those without such histories. +Evidence Rating Level: 2 (Good) +Major depressive disorder (MDD) is the world’s leading cause of disability, with increasing evidence of substantial heterogeneity in terms of presentations and treatment outcomes. This examination of two case-control studies of 58,328 participants across countries of low, middle, and high income sought to investigate impaired mood homeostasis and its associations with low mood and a history of MDD. The first data set, (58sec data set) recruited young adults (mean [SD] age = 28.1 [9.0] years, 65.8% female) in high-income francophone countries. The second data set (World Health Organization Study on Global Aging and Adult Health [WHO SAGE] data set) included representative samples from Ghana, China, India, Russia, Mexico, and South Africa (mean [SD] age = 57.8 [14.7] years, 57.0% female). Impaired mood homeostasis was defined as “the extent to which a person preferentially engages in mood-increasing activities such as exercising when their mood is low and saves the mood-decreasing activities such as house-work for when their mood is higher.” Through the use of self-report data pertaining to mood homeostasis, it was determined that participants with low mean mood reported significantly lower levels of mood homeostasis (0.63, 95% CI 0.45 to 0.79) compared to those with high mean mood (0.96, 95% CI 0.96 to 0.98, p<0.001). Individuals with a history of MDD also had lower levels of mood homeostasis (0.03, 95% CI -0.26 to 0.24) than those without a history of MDD (0.68, 95% CI 0.55 to 0.75, p<0.001). Lower mood homeostasis was found to lead to a greater number of depressive episodes (difference 8.0% annual risk, p<0.001) as well as longer durations of these episodes (difference 1.29 weeks, p = 0.006) in dynamic simulations. The findings of this study suggest that mood homeostasis may serve a meaningful role in better understanding the heterogeneity of MDD. Those with a history of MDD and/or low mean mood should be assessed for impaired mood homeostasis. +Click to read the study in JAMA Psychiatry +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.