Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Chan A, Shah R. Chan A, & Shah R Chan, Alex, and Ravi Shah. Early aortic valve replacement linked with improved outcomes versus conservative management. 2 Minute Medicine, 16 March 2020. McGraw-Hill, 2020. AccessMedicine. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=538489§ionid=241991998APA Citation Chan A, Shah R. Chan A, & Shah R Chan, Alex, and Ravi Shah. (2020). Early aortic valve replacement linked with improved outcomes versus conservative management. (2020). 2 minute medicine. McGraw-Hill. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=538489§ionid=241991998.MLA Citation Chan A, Shah R. Chan A, & Shah R Chan, Alex, and Ravi Shah. "Early aortic valve replacement linked with improved outcomes versus conservative management." 2 Minute Medicine McGraw-Hill, 2020, https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=538489§ionid=241991998. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Full Chapter Figures Only Tables Only Videos Only Supplementary Content Top Early aortic valve replacement linked with improved outcomes versus conservative management by Alex Chan, Ravi Shah Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Patients with asymptomatic severe aortic stenosis receiving early valve replacement had a lower incidence of operative mortality or death due to cardiovascular causes compared to patients receiving conservative care +Evidence Level: 1 (Excellent) +Aortic stenosis is the most common valvular disease with surgical indications in developed countries, with aortic-valve replacement being the only effective treatment option for severe symptomatic stenosis. Currently, the consensus opinion is to reserve surgical intervention for patients with symptomatic severe aortic stenosis, with observation and conservative management for asymptomatic patients. In asymptomatic patients, surgical risks have been largely regarded as outweighing the potential benefits of valve replacement. Advancements in surgical techniques, technology, and postoperative care, however, have raised questions surrounding the safety of performing valve replacement earlier in asymptomatic patients. In this multicenter, randomized controlled trial, 145 asymptomatic patients with very severe aortic stenosis (aortic-valve area of ≤0.75 cm2 with either an aortic jet velocity of ≥4.5 m per second or a mean transaortic gradient of ≥50 mm Hg) between July 2010 through April 2015 to either undergo early surgery group or receive conservative care. The primary end point was a composite of operative mortality, consisting of death during or within 30 days of surgery, or death from cardiovascular causes during the entire follow up period (median follow up 6.2 years). Researchers found there was no operative mortality found in the early intervention group, and, in an intention-to-treat analysis, the early treatment group had significantly fewer end events compared to the conservative treatment group (HR 0.09, 95% CI 0.01 to 0.67, p=0.003). The incidence of death due to any cause was also lower in the intervention group compared to the conservative treatment group. This study therefore supports earlier surgical intervention for asymptomatic patients with very severe aortic stenosis, with reduced operative risk possibly owing to improved surgical technique and postoperative care. +Click to read the study in NEJM +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.