Print Get Citation Citation Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Jackson A. Jackson A Jackson, Ashley. Antidepressants are effective in patients with comorbid depression and medical diseases. 2 Minute Medicine, 18 September 2023. McGraw Hill, 2023. AccessMedicine. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=629965§ionid=281496243APA Citation Jackson A. Jackson A Jackson, Ashley. (2023). Antidepressants are effective in patients with comorbid depression and medical diseases. (2023). 2 minute medicine. McGraw Hill. https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=629965§ionid=281496243.MLA Citation Jackson A. Jackson A Jackson, Ashley. "Antidepressants are effective in patients with comorbid depression and medical diseases." 2 Minute Medicine McGraw Hill, 2023, https://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=629965§ionid=281496243. Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Annotate Clip Autosuggest Results Antidepressants are effective in patients with comorbid depression and medical diseases by Ashley Jackson Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. This umbrella systematic review and meta-analysis found that depression rating scale scores were significantly improved across medical diseases in patients with comorbid depression compared to placebo. +2. However, antidepressants showed the greatest effect for treating depression comorbid with myocardial infarction, functional chest pain, and coronary artery disease. They demonstrated the least effect for low back pain and traumatic brain injury. +Evidence Rating Level: 1 (Excellent) +Major depression disorder (MDD) is highly prevalent among individuals with other medical conditions. Although anti-depressants are the first-line treatment for MDD, most studies that investigate the safety and efficacy of anti-depressants exclude patients with other comorbidities. As such, the use of antidepressants in the treatment of comorbid depression in patients with other medical diseases is poorly understood. Therefore, this study aimed to assess the safety and efficacy of antidepressants in patients with medical conditions and comorbid depression. +Of 6,587 identified records, 176 systematic reviews (n=43 medical diseases) and 52 meta-analyses (n=27 medical diseases) were included from database inception to March 2023. Studies were included if they were systematic reviews of randomized controlled trials that investigated the treatment of comorbid depression and medical diseases with antidepressants compared to placebo or active control groups. Studies were if the efficacy and tolerability of antidepressants was not explored or if depression was comorbid with another mental disorder. The review was carried out according to PRISMA guidelines. The primary outcome was the efficacy of antidepressants in the treatment of comorbid depression, as determined by depression rating scale scores. +The results demonstrated that antidepressants were associated with significant improvements in depression rating scale scores compared to placebo. Antidepressants showed the greatest improvement in depressive symptoms for depression comorbid with myocardial infarction, functional chest pain, and coronary artery disease. Meanwhile, the smallest improvement was seen for depression comorbid with low back pain and traumatic brain injury. Antidepressants showed worse acceptability and tolerability than placebo but led to higher response rates and remission rates than placebo. However, the review was limited by the inclusion of studies without details on tolerability and acceptability, which may have impacted the results. Nonetheless, the study demonstrated that antidepressants are effective in treating depression comorbid with other medical conditions. +Click to read the study in JAMA Psychiatry +©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.