The intended audiences for DeGowin’s Diagnostic Examination Flashcards are all clinicians caring for patients, including medical students, residents, attending physicians, and clinicians in practice. New knowledge is best retained when acquired at the point of care, when it is relevant and necessary. Therefore, each flashcard is built around a common patient complaint or physical finding illustrated by a clinical vignette to demonstrate an essential concept used in framing diagnostic hypotheses. Each provides insight into the process by which the differential diagnosis is constructed using pathophysiologic and anatomic clues. Along with factual information stored in long-term memory, these flashcards will facilitate development and implementation of diagnostic strategies using memory schemes that represent and interrelate clinical problems.