If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.
Gamma-aminobutyric acid (GABA) A receptor-positive modulator
Alcohol, anesthetics (desflurane, etomidate, isoflurane, Methohexital, propofol, sevoflurane), barbiturates, benzodiazepines, Z-compounds (eszopiclone, zaleplon, zolpidem)
Chapter 19. Hypnotics and Sedatives > The GABA A Receptor
eChapter 2018: The Goodman & Gilman Year in Review New and Noteworthy FDA Approvals
Brexanolone is administered as a single 60-hour infusion, under continuous monitoring, in a controlled healthcare environment.56 Due to an association with excessive sedation and sudden loss of consciousness during administration, it is only available through the ZULRESSO REMS restricted access program which requires enrollment of healthcare facilities, pharmacies, patients, and drug wholesalers/distributors.56 Therapy with brexanolone is expected to cost approximately $34,000 per infusion.60