+Gamma-aminobutyric acid (GABA) A receptor-positive modulator
Agents with Similar Pharmacology
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+Alcohol, anesthetics (desflurane, etomidate, isoflurane, Methohexital, propofol, sevoflurane), barbiturates, benzodiazepines, Z-compounds (eszopiclone, zaleplon, zolpidem)
Further Reading in Goodman & Gilman
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+Brexanolone is administered as a single 60-hour infusion, under continuous monitoring, in a controlled healthcare environment.56 Due to an association with excessive sedation and sudden loss of consciousness during administration, it is only available through the ZULRESSO REMS restricted access program which requires enrollment of healthcare facilities, pharmacies, patients, and drug wholesalers/distributors.56 Therapy with brexanolone is expected to cost approximately $34,000 per infusion.60