RT Book, Section
A1 Dhodapkar, Madhav
A1 Mackall, Crystal L.
A1 Steinman, Ralph M.
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121090096
T1 Dendritic Cells and Adaptive Immunity
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK accessmedicine.mhmedical.com/content.aspx?aid=1121090096
RD 2024/04/16
AB SUMMARYDendritic  cells  are  a  multifunctional  group  of  cells  that  serve  as  sentinels  of  the  immune  system  and  thus  regulate  many  immune  functions.*  Dendritic  cells  play  a  central  role  in  initiating  adaptive  immune  responses  to  pathogens  and  initiating  antitumor  immune  responses.  Dendritic  cell  receptors  sense  environmental  stimuli  and  can  respond  rapidly  to  both  foreign  pathogens  and  danger  signals  derived  from  tissue  damage  or  immune  complexes.  Through  their  capacity  to  present  antigen  to  T  cells  in  immune-activating  or  immune-dampening  contexts,  dendritic  cells  can  both  induce  T-cell  proliferation  (activation)  or  lack  of  activation  (tolerance).  In  this  way,  dendritic  cells  help  regulate  immune  responses  mediated  by  T  cells  and  B  cells  of  the  adaptive  immune  system.  This  chapter  describes  the  varied  types  and  functions  of  this  important  class  of  cells.