RT Book, Section A1 Durkalski-Mauldin, Valerie L. A1 Brady, Kathleen T. A2 Greenberg, Raymond S. SR Print(0) ID 1108590235 T1 Clinical Trials T2 Medical Epidemiology: Population Health and Effective Health Care, 5e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-182272-5 LK accessmedicine.mhmedical.com/content.aspx?aid=1108590235 RD 2024/03/28 AB Stroke is a potentially debilitating medical event that affects approximately 800,000 people in the United States each year, leaving as many as 30% of survivors permanently disabled. Given this impact, there is great demand for treatments that significantly improve functional outcome after a stroke. To date, few clinical trials for the treatment of acute stroke have succeeded. Suppose you and a team of collaborators have a new treatment that you would like to test for use in patients who have had strokes. Where do you begin? How many patients do you need to sample to know if your treatment is safe and effective? How do you choose a comparison group and allocate treatment? How do you choose the outcome of interest and conduct the analysis of your data? These questions will be addressed in the following sections.