RT Book, Section A1 Schweickert, William D. A2 Grippi, Michael A. A2 Elias, Jack A. A2 Fishman, Jay A. A2 Kotloff, Robert M. A2 Pack, Allan I. A2 Senior, Robert M. A2 Siegel, Mark D. SR Print(0) ID 1122372478 T1 Early Mobilization of Patients in the ICU T2 Fishman's Pulmonary Diseases and Disorders, 5e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179672-9 LK accessmedicine.mhmedical.com/content.aspx?aid=1122372478 RD 2024/04/18 AB Improvements in diagnosis and resuscitation of critically ill patients have prompted investigation into the burden of “survivorship.”1–5 Observational research has described substantial morbidity in survivors of critical illness, including general deconditioning, muscle weakness, dyspnea, depression, anxiety, and reduced health-related quality of life.6 A major catalyst for widespread attention was the comprehensive observations on a cohort of survivors of acute respiratory distress syndrome (ARDS).7 In this case series, patients were young and generally healthy prior to ARDS, and they experienced severe illness with prolonged critical care. Despite severe acute lung injury, serial follow-up examinations demonstrated that lung function generally normalized during the first year after ICU discharge. In contrast, all patients reported poor function attributed to the loss of muscle bulk, proximal limb weakness, and fatigue. Patients exhibited impaired endurance, and only 49% of patients had returned to work. At 5 years after ICU discharge, subjective weakness and decreased exercise capacity continued.8 Although 77% of patients were working by the fifth year, patients often required a modified work schedule, gradual transition back to work, or job retraining. In addition, patients were plagued with psychological illness. More than half of survivors experienced at least one episode of depression or anxiety.