RT Book, Section A1 Tobin, Martin J. A2 Grippi, Michael A. A2 Elias, Jack A. A2 Fishman, Jay A. A2 Kotloff, Robert M. A2 Pack, Allan I. A2 Senior, Robert M. A2 Siegel, Mark D. SR Print(0) ID 1122372270 T1 Principles of Mechanical Ventilation T2 Fishman's Pulmonary Diseases and Disorders, 5e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179672-9 LK accessmedicine.mhmedical.com/content.aspx?aid=1122372270 RD 2024/03/28 AB The historical evolution of mechanical ventilation is rich and built on advances in many fields, including endeavors by anatomists, chemists, explorers, physiologists, and clinicians.1 In 1543, Vesalius demonstrated that positive-pressure ventilation could be used to resuscitate a dying animal. Bellows ventilation was advocated by various lay bodies in the resuscitation of near-drowning victims late in the 18th century. In 1827, however, Leroy demonstrated that overzealous bellows inflation could result in pneumothoraces. Official bodies condemned the technique, and, thus, early in its infancy, positive-pressure ventilation was banned from use. Around this time, negative-pressure ventilators were developed and later popularized as a panacea for a wide variety of ailments.