RT Book, Section
A1 Kelsen, Steven G.
A2 Grippi, Michael A.
A2 Elias, Jack A.
A2 Fishman, Jay A.
A2 Kotloff, Robert M.
A2 Pack, Allan I.
A2 Senior, Robert M.
A2 Siegel, Mark D.
SR Print(0)
ID 1122371470
T1 Pump Failure: The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease
T2 Fishman's Pulmonary Diseases and Disorders, 5e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179672-9
LK accessmedicine.mhmedical.com/content.aspx?aid=1122371470
RD 2024/04/18
AB The  ventilatory  pump  accomplishes  bulk  transfer  of  air  to  and  from  the  alveoli.  Accordingly,  diseases  that  perturb  the  mechanical  properties  of  any  component  of  the  ventilatory  pump  (i.e.,  the  bony  rib  cage,  the  extra-  and  intrathoracic  conducting  airways,  and  the  respiratory  muscles)  may  interfere  with  CO2  elimination  and  O2  uptake.  If  disturbances  in  the  function  of  the  ventilatory  pump  are  sufficiently  severe,  alveolar  hypoventilation  and  respiratory  acidosis  may  ensue.  Hypercapnic  respiratory  failure  is  defined  as  a  steady-state  PaCO2  while  awake  at  more  than  45  mm  Hg,  the  upper  limit  of  normal.  This  definition  is  somewhat  arbitrary  but  has  proved  clinically  useful.