RT Book, Section
A1 Standiford, Theodore J.
A1 Toews*, Galen B.
A1 Huffnagle, Gary B.
A2 Grippi, Michael A.
A2 Elias, Jack A.
A2 Fishman, Jay A.
A2 Kotloff, Robert M.
A2 Pack, Allan I.
A2 Senior, Robert M.
A2 Siegel, Mark D.
SR Print(0)
ID 1122368239
T1 Pulmonary Clearance of Infectious Agents
T2 Fishman's Pulmonary Diseases and Disorders, 5e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179672-9
LK accessmedicine.mhmedical.com/content.aspx?aid=1122368239
RD 2021/01/24
AB The  primary  function  of  the  lungs  is  the  exchange  of  gases  at  a  rate  required  to  support  tissue  metabolism.  During  gas  exchange,  the  lung  is  continuously  exposed  to  a  varied  burden  of  foreign  substances,  including  infectious  agents.  In  addition,  the  lung  is  repeatedly  challenged  with  microbes  via  aspiration  of  secretions  from  the  upper  respiratory  tract,  particularly  during  sleep.  The  lung  must  defend  itself  against  this  potentially  hostile  environment  while  maintaining  the  alveolar  architecture  required  for  adequate  gas  exchange.  This  group  of  nonrespiratory  functions  has  been  collectively  termed  pulmonary  host  defenses.1