RT Book, Section A1 Chang, Lydia A1 Rivera, M. Patricia A2 Grippi, Michael A. A2 Elias, Jack A. A2 Fishman, Jay A. A2 Kotloff, Robert M. A2 Pack, Allan I. A2 Senior, Robert M. A2 Siegel, Mark D. SR Print(0) ID 1122367341 T1 Clinical Evaluation, Diagnosis, and Staging of Lung Cancer T2 Fishman's Pulmonary Diseases and Disorders, 5e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179672-9 LK accessmedicine.mhmedical.com/content.aspx?aid=1122367341 RD 2023/05/30 AB Patients who present with suspected lung cancer require a detailed clinical evaluation followed by noninvasive testing and invasive procedures to establish both the histopathologic diagnosis as well as disease stage. Historically, great emphasis has been placed upon the differentiation of small-cell lung cancer (SCLC) from non–small-cell lung cancer (NSCLC). SCLC, which accounts for 14% of bronchogenic carcinomas, is histologically and clinically distinct from NSCLC.1 NSCLCs have been traditionally regarded as a fairly uniform group of cancers. However, it has become increasingly evident that NSCLCs are comprised of clinically, pathologically, and molecularly diverse tumors that respond to different therapeutic agents based on specific histologic phenotypes and molecular characteristics.