RT Book, Section
A1 Pien, Grace W.
A1 Rosen, Ilene M.
A1 Fields, Barry G.
A2 Grippi, Michael A.
A2 Elias, Jack A.
A2 Fishman, Jay A.
A2 Kotloff, Robert M.
A2 Pack, Allan I.
A2 Senior, Robert M.
A2 Siegel, Mark D.
SR Print(0)
ID 1122366079
T1 Sleep Apnea Syndromes: Central and Obstructive
T2 Fishman's Pulmonary Diseases and Disorders, 5e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179672-9
LK accessmedicine.mhmedical.com/content.aspx?aid=1122366079
RD 2024/04/24
AB Sleep-disordered  breathing  (SDB)  is  an  extremely  common  medical  disorder  associated  with  important  morbidity.  Recognition  of  its  relevance  in  medicine  is  relatively  recent,  although  clinical  reports  of  SDB  were  first  made  in  the  19th  century.1  Likely  influenced  by  such  observations,  descriptions  of  an  entity  constituting  obesity  and  extreme  somnolence  were  highlighted  in  the  character  narratives  of  the  “fat  boy”  in  Charles  Dickens’  series,  Posthumous  Papers  of  the  Pickwick  Club,  first  published  in  1837.2  Dickens  described  Joe,  the  fat  boy,  as  a  loud  snorer  who  was  obese  and  excessively  somnolent—the  classical  description  of  Pickwickian  syndrome.  Sir  William  Osler  in  1918  was  credited  with  first  linking  the  relationship  between  obesity  and  Pickwickian  syndrome.3  In  the  mid-20th  century,  further  work  led  to  the  association  of  Pickwickian  syndrome  with  alveolar  hypoventilation  by  Burwell  et  al.  in  1956,  and  periodic  cessation  of  respiration  by  Drachman  and  Gumnit  in  1962.4,5