RT Book, Section
A1 Specks, Ulrich
A2 Grippi, Michael A.
A2 Elias, Jack A.
A2 Fishman, Jay A.
A2 Kotloff, Robert M.
A2 Pack, Allan I.
A2 Senior, Robert M.
A2 Siegel, Mark D.
SR Print(0)
ID 1122362899
T1 Pulmonary Vasculitis
T2 Fishman's Pulmonary Diseases and Disorders, 5e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179672-9
LK accessmedicine.mhmedical.com/content.aspx?aid=1122362899
RD 2020/09/19
AB Pulmonary  vasculitis  is  usually  a  manifestation  of  a  systemic  disorder  leading  to  inflammation  of  vessels  of  different  sizes  by  a  variety  of  immunological  mechanisms.  Vasculitis  can  be  categorized  into  primary  vasculitis  and  secondary  vasculitis.  The  primary  systemic  vasculitides  are  a  heterogeneous  group  of  syndromes  of  unknown  etiology,  which  share  a  clinical  response  to  immunosuppressive  therapy  (Table  74-1).  Their  wide  spectrum  of  frequently  overlapping  clinical  manifestations  is  defined  by  the  size  and  location  of  the  affected  vessels  as  well  as  the  nature  of  the  inflammatory  infiltrate.  Secondary  vasculitis  may  represent  significant  management  problems  in  the  context  of  a  well-defined  underlying  disorder,  such  as  diffuse  alveolar  hemorrhage  caused  by  systemic  lupus  erythematosus  (SLE).  Alternatively,  secondary  vasculitis  may  be  an  incidental  histopathological  finding,  for  instance,  in  the  context  of  an  infection  or  necrotizing  sarcoid  granulomatosis.