RT Book, Section A1 Martinez, Fernando J. A2 Grippi, Michael A. A2 Elias, Jack A. A2 Fishman, Jay A. A2 Kotloff, Robert M. A2 Pack, Allan I. A2 Senior, Robert M. A2 Siegel, Mark D. SR Print(0) ID 1122360256 T1 Bullous Disease of the Lung T2 Fishman's Pulmonary Diseases and Disorders, 5e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179672-9 LK accessmedicine.mhmedical.com/content.aspx?aid=1122360256 RD 2023/01/28 AB A bulla is an air-containing space within the lung parenchyma that arises from destruction, dilatation, and confluence of airspaces distal to terminal bronchioles and is larger than 1 cm in diameter (Fig. 52-1).1 Its walls are composed of attenuated and compressed parenchyma. Bullae occur in various clinical contexts: (1) with emphysema (“bullous emphysema”); (2) with pulmonary fibrosis, as in the late stages of sarcoidosis or complicated pneumoconiosis; (3) in so-called “vanishing lung,” in which the parenchyma is rapidly replaced by multiple bullae; and (4) in lungs that are otherwise normal (“bullous lung disease”) and, therefore, likely secondary to a mechanism different from that of bullae occurring in conjunction with emphysema (Table 52-1).2,3