RT Book, Section A1 Yandle, Gretchen A1 deBoisblanc, Bennett P. A2 Hall, Jesse B. A2 Schmidt, Gregory A. A2 Kress, John P. SR Print(0) ID 1107719834 T1 Persistent Fever T2 Principles of Critical Care, 4e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071738811 LK accessmedicine.mhmedical.com/content.aspx?aid=1107719834 RD 2024/10/04 AB Fever occurs in more than 50% of patients at some time during their ICU stay.Approximately 50% of fevers are due to noninfectious causes, such as drug fevers, surgical trauma, and central nervous system injury.A thoughtful evaluation of a fever may reduce costs and lessen the potential risk to the patient.Extreme elevations of temperature (>41.1°C) are most often not due to infectious etiologies.Heat stroke, serotonin syndrome, neuroleptic malignant syndrome, and malignant hyperthermia are life-threatening causes of hyperpyrexia that must be immediately recognized and treated in order to avoid multisystem organ failure and death.Although fever is associated with adverse outcomes in the ICU, there is no conclusive evidence to support the routine treatment of fever due to infection in non-brain-injured patients.