RT Book, Section A1 Hasler, William L. A1 Owyang, Chung A2 Kasper, Dennis A2 Fauci, Anthony A2 Hauser, Stephen A2 Longo, Dan A2 Jameson, J. Larry A2 Loscalzo, Joseph SR Print(0) ID 1120810257 T1 Approach to the Patient with Gastrointestinal Disease T2 Harrison's Principles of Internal Medicine, 19e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071802154 LK accessmedicine.mhmedical.com/content.aspx?aid=1120810257 RD 2021/04/15 AB The gastrointestinal (GI) tract extends from the mouth to the anus and is composed of several organs with distinct functions. Specialized independently controlled thickened sphincters that assist in gut compartmentalization separate the organs. The gut wall is organized into well-defined layers that contribute to functional activities in each region. The mucosa is a barrier to luminal contents or a site for transfer of fluids or nutrients. Gut smooth muscle in association with the enteric nervous system mediates propulsion from one region to the next. Many GI organs possess a serosal layer that provides a supportive foundation but that also permits external input.