RT Book, Section
A1 Libby, Peter
A2 Kasper, Dennis
A2 Fauci, Anthony
A2 Hauser, Stephen
A2 Longo, Dan
A2 Jameson, J. Larry
A2 Loscalzo, Joseph
SR Print(0)
ID 1120806271
T1 The Pathogenesis, Prevention, and Treatment of Atherosclerosis
T2 Harrison's Principles of Internal Medicine, 19e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071802154
LK accessmedicine.mhmedical.com/content.aspx?aid=1120806271
RD 2021/01/22
AB Atherosclerosis  remains  the  major  cause  of  death  and  premature  disability  in  developed  societies.  Moreover,  current  predictions  estimate  that  by  the  year  2020  cardiovascular  diseases,  notably  atherosclerosis,  will  become  the  leading  global  cause  of  total  disease  burden.  Although  many  generalized  or  systemic  risk  factors  predispose  to  its  development,  atherosclerosis  affects  various  regions  of  the  circulation  preferentially  and  has  distinct  clinical  manifestations  that  depend  on  the  particular  circulatory  bed  affected.  Atherosclerosis  of  the  coronary  arteries  commonly  causes  myocardial  infarction  (MI)  (Chap.  295)  and  angina  pectoris  (Chap.  293).  Atherosclerosis  of  the  arteries  supplying  the  central  nervous  system  frequently  provokes  strokes  and  transient  cerebral  ischemia  (Chap.  446).  In  the  peripheral  circulation,  atherosclerosis  causes  intermittent  claudication  and  gangrene  and  can  jeopardize  limb  viability.  Involvement  of  the  splanchnic  circulation  can  cause  mesenteric  ischemia.  Atherosclerosis  can  affect  the  kidneys  either  directly  (e.g.,  renal  artery  stenosis)  or  as  a  common  site  of  atheroembolic  disease  (Chap.  301).