RT Book, Section
A1 Marcucci, Guido
A1 Bloomfield, Clara D.
A2 Kasper, Dennis
A2 Fauci, Anthony
A2 Hauser, Stephen
A2 Longo, Dan
A2 Jameson, J. Larry
A2 Loscalzo, Joseph
SR Print(0)
ID 1120794295
T1 Acute Myeloid Leukemia
T2 Harrison's Principles of Internal Medicine, 19e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071802154
LK accessmedicine.mhmedical.com/content.aspx?aid=1120794295
RD 2021/01/21
AB Acute  myeloid  leukemia  (AML)  is  a  neoplastic  disease  characterized  by  infiltration  of  the  blood,  bone  marrow,  and  other  tissues  by  proliferative,  clonal  undifferentiated  cells  of  the  hematopoietic  system.  These  leukemias  comprise  a  spectrum  of  malignancies  that,  untreated,  range  from  rapidly  fatal  to  slowly  growing.  In  2013,  the  estimated  number  of  new  AML  cases  in  the  United  States  was  14,590.  The  incidence  of  AML  is  ~3.5  per  100,000  people  per  year,  and  the  age-adjusted  incidence  is  higher  in  men  than  in  women  (4.5  vs  3.1).  AML  incidence  increases  with  age;  it  is  1.7  in  individuals  age  65  years.  The  median  age  at  diagnosis  is  67  years.