RT Book, Section
A1 Barbara, A. Konkle
A2 Kasper, Dennis
A2 Fauci, Anthony
A2 Hauser, Stephen
A2 Longo, Dan
A2 Jameson, J. Larry
A2 Loscalzo, Joseph
SR Print(0)
ID 1120790268
T1 Bleeding and Thrombosis
T2 Harrison's Principles of Internal Medicine, 19e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071802154
LK accessmedicine.mhmedical.com/content.aspx?aid=1120790268
RD 2021/04/19
AB The  human  hemostatic  system  provides  a  natural  balance  between  procoagulant  and  anticoagulant  forces.  The  procoagulant  forces  include  platelet  adhesion  and  aggregation  and  fibrin  clot  formation;  anticoagulant  forces  include  the  natural  inhibitors  of  coagulation  and  fibrinolysis.  Under  normal  circumstances,  hemostasis  is  regulated  to  promote  blood  flow;  however,  it  is  also  prepared  to  clot  blood  rapidly  to  arrest  blood  flow  and  prevent  exsanguination.  After  bleeding  is  successfully  halted,  the  system  remodels  the  damaged  vessel  to  restore  normal  blood  flow.  The  major  components  of  the  hemostatic  system,  which  function  in  concert,  are  (1)  platelets  and  other  formed  elements  of  blood,  such  as  monocytes  and  red  cells;  (2)  plasma  proteins  (the  coagulation  and  fibrinolytic  factors  and  inhibitors);  and  (3)  the  vessel  wall.