RT Book, Section
A1 Cohn, Lauren E.
A2 Grippi, Michael A.
A2 Elias, Jack A.
A2 Fishman, Jay A.
A2 Kotloff, Robert M.
A2 Pack, Allan I.
A2 Senior, Robert M.
A2 Siegel, Mark D.
SR Print(0)
ID 1122356229
T1 T Lymphocytes in the Lung
T2 Fishman's Pulmonary Diseases and Disorders, 5e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179672-9
LK accessmedicine.mhmedical.com/content.aspx?aid=1122356229
RD 2024/10/04
AB The  lung  is  a  major  site  of  exposure  to  the  outside  world  in  air-breathing  species.  Lung  immunity  has  developed  to  recognize  pathogens  and  activate  appropriate  responses,  to  temper  inflammation  in  response  to  nonpathogenic  exposures  and  turn  off  immune  responses  when  danger  signals  have  been  eliminated.  T  lymphocytes  play  a  major  role  in  lung  immunity  predominantly  through  the  induction  of  CD4  and  CD8  T  cells  in  adaptive  immunity.  A  number  of  smaller  subsets  of  T  lymphocytes  also  play  critical  roles  in  early  immune  responses  to  pathogens  and  stimulating  adaptive  immune  responses.  Long-lived  memory  CD4  and  CD8  T  cells  are  crucial  for  host  protection  from  pathogens,  but  also  may  drive  chronic  disease  states,  such  as  asthma.  In  this  chapter  the  basic  biology  of  T  lymphocytes  and  their  relevance  in  the  lung  in  health  and  disease  will  be  reviewed.