RT Book, Section A1 Twigg, Homer L. A2 Grippi, Michael A. A2 Elias, Jack A. A2 Fishman, Jay A. A2 Kotloff, Robert M. A2 Pack, Allan I. A2 Senior, Robert M. A2 Siegel, Mark D. SR Print(0) ID 1122356150 T1 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency T2 Fishman's Pulmonary Diseases and Disorders, 5e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179672-9 LK accessmedicine.mhmedical.com/content.aspx?aid=1122356150 RD 2024/11/13 AB Antibody-mediated, or humoral, immunity is essential for host defense against respiratory pathogens. Defects in humoral immunity are common and frequently underappreciated. From a respiratory perspective, patients with impaired humoral immunity are susceptible to recurrent bacterial sinopulmonary infections and bronchiectasis. Antibody responses are also the principal mechanism behind the efficacy of vaccination against respiratory pathogens. This chapter focuses on our understanding of the normal B cell environment in the lung, generation of appropriate antibody responses after antigenic challenge, disease states associated with impaired lung humoral immunity, and the pulmonary response to vaccination.