RT Book, Section
A1 Bunn, H. Franklin
A2 Bunn, H. Franklin
A2 Aster, Jon C.
SR Print(0)
ID 1104131137
T1 Sickle Cell Disease
T2 Pathophysiology of Blood Disorders
YR 2011
FD 2011
PB McGraw-Hill Medical
PP New York, NY
SN 9780071713788
LK accessmedicine.mhmedical.com/content.aspx?aid=1104131137
RD 2024/04/23
AB LEARNING  OBJECTIVESAfter  studying  this  chapter  you  should  understand:The  inheritance  of  sickle  cell  disease  and  the  difference  between  hemoglobin  SS  homozygotes,  hemoglobin  AS  heterozygotes,  and  compound  heterozygotes  (hemoglobin  SC  and  hemoglobin  S/β-thalassemia).The  molecular  basis  for  polymerization  of  deoxyhemoglobin  S.The  process  of  sickle  vaso-occlusion.The  clinical  manifestations  of  sickle  cell  disease:  acute  pain  crises  and  progressive  organ  damage.The  treatment  of  sickle  cell  disease:  supportive  care  and  prevention  of  sickling.