RT Book, Section
A1 Janssen, Sarah
A2 LaDou, Joseph
A2 Harrison, Robert J.
SR Print(0)
ID 1104104597
T1 Female Reproductive Toxicology
T2 CURRENT Diagnosis & Treatment:  Occupational & Environmental Medicine, 5e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071808156
LK accessmedicine.mhmedical.com/content.aspx?aid=1104104597
RD 2024/04/20
AB The  occurrence  of  adverse  reproductive  outcomes  is  of  fundamental  concern  to  the  individuals  and  families  affected.  This  is  especially  true  if  the  individuals  perceive  that  they  are  living  or  working  in  areas  with  potential  exposure  to  hazardous  agents  over  which  they  have  little  or  no  control.  Concern  has  been  fueled  by  incidents  such  as  the  contamination  of  fish  with  methyl  mercury  in  Minamata  Bay,  Japan,  which  was  caused  by  a  release  from  a  manufacturing  plant.  Consumption  of  the  contaminated  fish  by  pregnant  women  resulted  in  an  epidemic  of  mental  retardation,  cerebral  palsy,  and  developmental  delay  in  their  offspring.  Use  of  polychlorinated  biphenyl  (PCB)–contaminated  cooking  oil  in  Taiwan  resulted  in  intrauterine  growth  retardation  and  hyperpigmentation  of  the  skin  in  infants  of  exposed  women.  Effects  on  that  cohort  continue  to  be  uncovered  today,  including  on  offspring  pubertal  development.  In  recent  years,  there  have  been  concerns  about  the  reproductive  effects  of  occupational  exposure  to  solvents,  pesticides,  and  video-display  terminals  or  electromagnetic  fields.  A  new  area  of  research  has  sprung  up  to  identify  and  study  chemicals  that  may  act  to  disrupt  the  endocrine  system,  affecting  both  wildlife  and  humans.