RT Book, Section A1 Xekouki, Paraskevi A1 Gourgari, Evgenia A1 Stratakis, Constantine A. A2 Murray, Michael F. A2 Babyatsky, Mark W. A2 Giovanni, Monica A. A2 Alkuraya, Fowzan S. A2 Stewart, Douglas R. SR Print(0) ID 1102701416 T1 Multiple Endocrine Neoplasia Type 1 T2 Clinical Genomics: Practical Applications in Adult Patient Care YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071622448 LK accessmedicine.mhmedical.com/content.aspx?aid=1102701416 RD 2024/03/28 AB Disease summary:The term multiple endocrine neoplasia 1 (MEN1) refers to a familial tumor syndrome characterized by the combination of tumors of the parathyroid glands, pancreatic islet cells, and anterior pituitary gland.Patients may also develop adrenal cortical tumors, carcinoid tumors, facial angiofibromas, collagenomas, and lipomas.Parathyroid tumors are the first manifestation of MEN1 in more than 85% of patients. In less than 15% of patients, the first manifestation may be an insulinoma or prolactinoma.The frequency of MEN1 is estimated to be 1 case in 30,000 persons with a female to male ratio of 1:1.The age of onset of endocrine tumors is usually in the teenaged years; however, the diagnosis is frequently delayed until the fourth decade of life.