RT Book, Section A1 Sager, Solomon A1 Dolinsky, Jill S. A1 Hershberger, Ray E. A2 Murray, Michael F. A2 Babyatsky, Mark W. A2 Giovanni, Monica A. A2 Alkuraya, Fowzan S. A2 Stewart, Douglas R. SR Print(0) ID 1102699424 T1 Dilated Cardiomyopathy T2 Clinical Genomics: Practical Applications in Adult Patient Care YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071622448 LK accessmedicine.mhmedical.com/content.aspx?aid=1102699424 RD 2024/10/07 AB Disease summary:Dilated cardiomyopathy (DCM) is characterized by left ventricular (LV) enlargement and systolic dysfunction.The prevalence of DCM is 1 in 2700, however, this is undoubtedly an underestimate.Histologic findings include myocyte hypertrophy, myocyte loss, and interstitial fibrosis.Approximately 35% of DCM cases are deemed idiopathic dilated cardiomyopathy (IDC) after detectable causes have been excluded (Fig. 24-1).20% to 50% of IDC may be found in one or more family members, and if so, is termed familial dilated cardiomyopathy (FDC). Of these cases, approximately 20% to 25% have identifiable genetic mutations correlating with disease phenotype.