RT Book, Section
A1 Brugada, Ramon
A1 Larrea, Oscar Campuzano
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102699350
T1 Brugada Syndrome and Related Cardiac Diseases
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessmedicine.mhmedical.com/content.aspx?aid=1102699350
RD 2024/04/19
AB Disease  summary:Brugada  syndrome  (BrS)  was  described  in  1992.  It  is  characterized  by  the  presence  of  a  typical  electrocardiographic  (ECG)  pattern  (right  bundle  branch  block  and  persistent  ST-segment  elevation  in  right  precordial  leads)  and  it  is  associated  with  sudden  cardiac  death  (SCD).  To  date,  it  is  supposed  to  be  responsible  for  4%  to  12%  of  total  SCD  cases,  and  20%  of  SCD  in  patients  with  structurally  normal  hearts.  The  prevalence  of  the  disease  is  difficult  to  estimate  because  the  pattern  is  not  always  recognized  or  because  it  may  transiently  normalize.  Nevertheless  it  is  believed  to  be  in  the  range  of  1  to  5  in  10,000,  being  higher  in  Southeast  Asia  where  the  disease  occurs  endemically.  The  average  age  of  diagnosis  is  usually  around  age  40,  however,  there  has  been  description  of  affected  individuals  from  age  1  to  84,  and  is  more  common  in  males  than  in  females  (8:1).  BrS  has  also  been  described  as  responsible  for  sudden  infant  death  syndrome  (SIDS).