RT Book, Section A1 Kiss, Daniel A1 Rader, Daniel J. A2 Murray, Michael F. A2 Babyatsky, Mark W. A2 Giovanni, Monica A. A2 Alkuraya, Fowzan S. A2 Stewart, Douglas R. SR Print(0) ID 1102698842 T1 Dyslipidemia T2 Clinical Genomics: Practical Applications in Adult Patient Care YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071622448 LK accessmedicine.mhmedical.com/content.aspx?aid=1102698842 RD 2024/03/28 AB Disease summary:Hyperlipidemia describes the phenotype of elevated blood lipids, predisposing a patient to atherosclerotic vascular disease. The overall heritability of blood lipids is often due to the interaction of a variety of alleles.Classic Mendelian monogenic lipoprotein disorders, while rare, have provided profound insight into lipoprotein metabolism and atherosclerotic vascular disease.Originally characterized by Fredrickson and Levy by the type of lipoprotein that accumulated in the circulation, the modern approach to classic Mendelian monogenic disorders emphasizes the molecular basis of the disease and the defect in cholesterol metabolism.Within the population, blood lipid variation is typically the consequence of variation at multiple loci, in addition to significant effect from the environment.