RT Book, Section A1 Barbul, Adrian A1 Efron, David T. A1 Kavalukas, Sandra L. A2 Brunicardi, F. Charles A2 Andersen, Dana K. A2 Billiar, Timothy R. A2 Dunn, David L. A2 Hunter, John G. A2 Matthews, Jeffrey B. A2 Pollock, Raphael E. SR Print(0) ID 1117741787 T1 Wound Healing T2 Schwartz's Principles of Surgery, 10e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071796743 LK accessmedicine.mhmedical.com/content.aspx?aid=1117741787 RD 2024/04/19 AB Wound healing is a complex cellular and biochemical cascade that leads to restitution of integrity and function.Although individual tissues may have unique healing characteristics, all tissues heal by similar mechanisms, and the process undergoes phases of inflammation, cellular migration, proliferation, matrix deposition, and remodeling.Factors that impede normal healing include local, systemic, and technical conditions that the surgeon must take into account.Clinically, excess healing can be as significant a problem as impaired healing; genetic, technical, and local factors play a major role.Optimal outcome of acute wounds relies on complete evaluation of the patient and of the wound and application of best practices and techniques.