RT Book, Section
A1 Shoback, Dolores M.
A1 Sellmeyer, Deborah E.
A2 Hammer, Gary D.
A2 McPhee, Stephen J.
SR Print(0)
ID 1100862150
T1 Disorders of the Parathyroids & Calcium & Phosphorus Metabolism
T2 Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-180600-8
LK accessmedicine.mhmedical.com/content.aspx?aid=1100862150
RD 2024/04/16
AB This  chapter  presents  a  general  overview  of  the  key  hormones  involved  in  the  regulation  of  calcium,  phosphate,  and  bone  mineral  metabolism.  These  include  parathyroid  hormone,  vitamin  D—principally  the  1,25-(OH)2  vitamin  D  metabolite  (1,25-dihydroxycholecalciferol)—calcitonin,  and  fibroblast  growth  factor  (FGF)-23.  The  cycle  of  bone  remodeling  is  described  as  a  basis  for  understanding  normal  maintenance  of  skeletal  integrity  in  adults  and  of  mineral  homeostasis.  The  symptoms  and  signs  caused  by  excess  or  deficiency  of  the  calciotropic  hormones  are  presented  along  with  the  natural  histories  of  primary  hyperparathyroidism,  familial  (benign)  hypocalciuric  hypercalcemia,  hypercalcemia  of  malignancy,  different  forms  of  hypoparathyroidism,  and  medullary  carcinoma  of  the  thyroid.  Two  of  the  most  commonly  encountered  causes  of  low  bone  mass—osteoporosis  and  osteomalacia—are  reviewed,  along  with  discussions  regarding  their  pathogenesis.