RT Book, Section A1 Mangla, Ashvarya A1 Gupta, Saurabh A2 Crawford, Michael H. SR Print(0) ID 57950546 T1 Chapter 3. Antiplatelet Therapy T2 CURRENT Diagnosis & Treatment Cardiology, 4e YR 2014 FD 2014 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-180127-0 LK accessmedicine.mhmedical.com/content.aspx?aid=57950546 RD 2022/05/26 AB Atherosclerosis is a leading cause of cardiovascular disease. Atherosclerotic plaques can acutely rupture, exposing a necrotic core that sets off the coagulation cascade, ultimately culminating in vascular occlusion. Activation of platelets is the initial event in this cascade and, depending on the vascular bed involved, can cause acute coronary syndromes, ischemic stroke, mesenteric ischemia, or acute limb ischemia. Antiplatelet therapy forms the core of treatment for both acute and chronic atherosclerotic disease. In this chapter, we will discuss antiplatelet therapy in the treatment of cardiovascular disease.