RT Book, Section
A1 Jaggi, Preeti
A1 Shulman, Stanford T.
A2 Imboden, John B.
A2 Hellmann, David B.
A2 Stone, John H.
SR Print(0)
ID 57274634
T1 Chapter 52. Rheumatic Fever
T2 CURRENT Diagnosis & Treatment: Rheumatology, 3e
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-163805-0
LK accessmedicine.mhmedical.com/content.aspx?aid=57274634
RD 2022/01/25
AB Acute  rheumatic  fever  (ARF)  is  a  systemic,  immune-mediated  disease  that  is  triggered  by  pharyngeal  infection  with  group  A  streptococci  (GAS).  Fever,  migratory  polyarthritis,  and  carditis  are  the  most  common  clinical  manifestations.  ARF  is  most  frequent  among  5–15  year  olds  with  a  declining  incidence  in  adults.  It  is  extremely  rare  in  children  under  age  3,  prompting  speculation  that  more  than  one  GAS  infection  is  needed  before  ARF  can  develop.  ARF  is  not  considered  a  sequela  of  cutaneous  GAS  infection.