RT Book, Section A1 Stone, John H. A2 Imboden, John B. A2 Hellmann, David B. A2 Stone, John H. SR Print(0) ID 57273396 T1 Chapter 35. Polyarteritis Nodosa T2 CURRENT Diagnosis & Treatment: Rheumatology, 3e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-163805-0 LK accessmedicine.mhmedical.com/content.aspx?aid=57273396 RD 2024/03/28 AB Subacute onset of constitutional complaints (eg, fever, weight loss, malaise, arthralgias), lower extremity nodules and ulcerations, mononeuritis multiplex, and intestinal angina (postprandial pain caused by the involvement of mesenteric vessels).Cutaneous polyarteritis nodosa (PAN) is a variant of the systemic disease in which vasculitis is limited to the skin, usually presenting as nodules that break down into ulcers.Angiogram or biopsy of an involved organ required for diagnosis.Angiography may reveal microaneurysms in the kidneys or gastrointestinal tract.Biopsies of the skin and peripheral nerves (with sampling of the adjacent muscle) are the least invasive ways of confirming the diagnosis histopathologically.