RT Book, Section A1 Marchie, Anthony A1 Freiberg, Andrew A. A1 Kwon, Young-Min A2 Imboden, John B. A2 Hellmann, David B. A2 Stone, John H. SR Print(0) ID 57271534 T1 Chapter 13. Approach to the Patient with a Painful Prosthetic Hip or Knee T2 CURRENT Diagnosis & Treatment: Rheumatology, 3e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-163805-0 LK accessmedicine.mhmedical.com/content.aspx?aid=57271534 RD 2024/04/18 AB A thorough clinical history and a detailed physical examination are essential to delineate various intrinsic and extrinsic causes of pain in patients with hip and knee total joint replacements.Radiographs with orthogonal and weight-bearing views should be ordered to assess signs of implant-related complications.Laboratory investigations should include both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as screening serologic markers for joint infection.A high index of suspicion for infection must always be maintained, especially in patients with comorbidities such as diabetes, inflammatory arthritis, and compromised immunity.Awareness of adverse soft-tissue reaction to metal wear debris in patients with painful metal-on-metal total hip replacements is important in light of its increasing use in young and active patients.