RT Book, Section A1 Bersten, Andrew D. A2 Tobin, Martin J. SR Print(0) ID 57081737 T1 Chapter 65. Fluid Management in the Ventilated Patient T2 Principles and Practice of Mechanical Ventilation, 3e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-173626-8 LK accessmedicine.mhmedical.com/content.aspx?aid=57081737 RD 2024/04/19 AB Fluid management during mechanical ventilation is complicated by both the influence of positive-airway pressure on normal homeostatic control of bodily fluids, and the interaction of mechanical ventilation with fluid status. Hypovolemia may lead to hemodynamic intolerance of positive-airway pressure, and fluid overload may result in both impaired gas exchange and respiratory mechanics and deleterious systemic effects. In patients with acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS), positive fluid balance has been associated with both fewer ventilator-free days, and longer intensive care unit (ICU) stay, and with mortality in prospective randomized1 and observational2 studies, respectively.