RT Book, Section A1 Marini, John J. A2 Tobin, Martin J. SR Print(0) ID 57070342 T1 Chapter 29. Mechanical Ventilation in the Acute Respiratory Distress Syndrome T2 Principles and Practice of Mechanical Ventilation, 3e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-173626-8 LK accessmedicine.mhmedical.com/content.aspx?aid=57070342 RD 2024/03/28 AB Few areas of critical care medicine have been the subject of as much investigative attention or clinical concern as the set of problems grouped under the label acute respiratory distress syndrome (ARDS). This syndrome, first formally described in 1967,1 continues to be recognized clinically as a rapidly developing impairment of pulmonary oxygen exchange accompanied by diffuse infiltrates and altered respiratory system mechanics that cannot be attributed solely to hydrostatic forces. Fueled by better characterization of innate pathophysiology and of iatrogenic factors, considerable progress has been made in recent years toward reducing the adverse consequences of this condition. Yet, after more than four decades, active debate continues regarding key elements of the ventilatory prescription and appropriate therapeutic targets.