RT Book, Section A1 Anaya, Daniel A. A1 Dellinger, E. Patchen A2 McKean, Sylvia C. A2 Ross, John J. A2 Dressler, Daniel D. A2 Brotman, Daniel J. A2 Ginsberg, Jeffrey S. SR Print(0) ID 56194452 T1 Chapter 50. Antimicrobial Prophylaxis in Surgery T2 Principles and Practice of Hospital Medicine YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-160389-8 LK accessmedicine.mhmedical.com/content.aspx?aid=56194452 RD 2024/11/02 AB Surgical site infection (SSI) is the most common complication in surgical patients. Significant advances have occurred over the last few decades resulting in better understanding of the relevant risk factors for SSI, and high-level evidence has identified specific preventive strategies that help reduce the incidence of SSI. With the introduction of asepsis and antisepsis, prophylactic antibiotics have had the most significant impact reducing the incidence of SSI. However, in order to achieve the benefits derived from their use and minimize potential undesired effects, practice of this strategy needs to follow specific basic principles.