RT Book, Section
A1 Falanga, Vincent
A1 Iwamoto, Satori
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56106991
T1 Chapter 248. Mechanisms of Wound Repair, Wound Healing, and Wound Dressing
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56106991
RD 2024/04/25
AB |PrintWound  Repair  at  a  GlanceAcute  and  chronic  wounds  are  different  but  overlap.In  acute  wounds,  there  is  an  orderly  progression  from  injury  to  coagulation,  inflammation,  proliferation,  cell  migration,  and  tissue  modeling.In  the  initial  phases,  a  wide  range  of  growth  factors,  including  platelet-derived  growth  factor  and  transforming  growth  factor-β1,  play  an  important  role.  In  the  proliferation/migration  and  modeling  phases,  tissue  matrix  metalloproteinases  (MMPs),  integrins,  basic  fibroblast  growth  factor,  and  endothelial  growth  factor  are  critical.  MMP-1,  MMP-9,  and  MMP-10  are  essential  for  remodeling.Moist  wounds  heal  faster,  and  a  variety  of  wound  dressings  are  now  available  to  fit  this  requirement.  They  include  transparent  films,  hydrocolloids,  foams,  alginates,  gels,  and  collagen-based  products.Chronic  wounds  are  different  from  acute  wounds  in  that  the  one-way  relationship  between  the  different  phases  is  lost.  Chronic  wounds  are  the  complex  result  of  ischemia,  pressure,  and  infection;  healing  is  highly  dependent  on  these  factors.Wound  healing  of  skin  grafts  is  also  different,  as  it  is  completely  dependent  on  revascularization,  be  it  true  neovascularization  or  inosculation.