RT Book, Section
A1 Souza, Aieska De
A1 Strober, Bruce E.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56096360
T1 Chapter 214. Principles of Topical Therapy
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56096360
RD 2024/04/19
AB |PrintPrinciples  of  Topical  Therapy  at  a  GlanceThe  efficacy  of  a  topically  applied  drug  depends  on  its  inherent  potency  and  on  its  ability  to  penetrate  skin.Some  factors  that  affect  penetration  include:  concentration  of  medication,  thickness  and  integrity  of  the  stratum  corneum,  frequency  of  application,  occlusiveness  of  the  vehicle,  and  compliance.Topical  formulations  (vehicles)  are  meant  to  enhance  the  beneficial  effects  of  the  medication.Either  the  vehicle  or  its  active  ingredient(s)  may  cause  local  toxicity.Topical  medications  may  induce  systemic  toxicity.