RT Book, Section A1 Katz, Kenneth A. A2 Goldsmith, Lowell A. A2 Katz, Stephen I. A2 Gilchrest, Barbara A. A2 Paller, Amy S. A2 Leffell, David J. A2 Wolff, Klaus SR Print(0) ID 56090705 T1 Chapter 200. Syphilis T2 Fitzpatrick's Dermatology in General Medicine, 8e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-166904-7 LK accessmedicine.mhmedical.com/content.aspx?aid=56090705 RD 2024/03/28 AB |PrintSyphilis at a GlanceA disease caused by the spirochete Treponema pallidum subspecies pallidum that is usually sexually transmitted.In the United States, syphilis disproportionately affects men who have sex with men and blacks.The most common and recognizable manifestations are usually cutaneous.Syphilis passes through four distinct clinical phases: Primary stage, characterized by a chancre.Secondary stage, characterized typically by skin eruption(s) with or without lymphadenopathy and organ disease.A latent period of varied duration, characterized by the absence of signs or symptoms of disease, with only reactive serologic tests as evidence of infection.Tertiary stage, with cutaneous, neurologic, or cardiovascular manifestations.The recommended treatment for most types of syphilis is benzathine penicillin G, with dose and administration schedule determined by disease stage.Persons with human immunodeficiency virus infection are at higher risk of treatment failure and to neurosyphilis.