RT Book, Section
A1 Tschachler, Erwin
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56089694
T1 Chapter 197. Human T-Lymphotropic Viruses
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56089694
RD 2024/04/19
AB |PrintHuman  T-Lymphotropic  Virus  1-Induced  Skin  Diseases  at  a  GlanceAn  estimated  10–20  million  people  are  infected  by  human  T-cell  lymphotropic  virus  type  1  (HTLV-1)  worldwide,  with  endemic  pockets  of  high  prevalence  in  Southern  Japan  and  the  Caribbean  islands.Infective  dermatitis  is  a  recalcitrant  form  of  eczema  occurring  in  HTLV-1-infected  children  in  the  Caribbean.Adult  T-cell  leukemia  (ATL)  shows  monoclonal  HTLV-1  provirus  integration  in  tumor  cells  and  occurs  in  four  clinical  variants,  all  of  which  tend  to  show  skin  involvement:Smoldering  ATL—5%  of  all  cases.Chronic  ATL—15%  of  all  cases.Lymphoma-type  ATL—20%  of  all  cases.Acute  ATL—60%  of  all  cases.The  prognosis  of  lymphoma-type  and  acute  ATL  is  very  poor  despite  chemotherapy,  with  a  projected  4-year  survival  of  5%.