RT Book, Section
A1 Kang, Insoo
A1 Craft, Joseph
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56075507
T1 Chapter 154. Mechanisms of Autoimmune Disease
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56075507
RD 2024/04/19
AB |PrintMechanisms  for  Autoimmune  Diseases  at  a  GlanceAutoimmune  diseases  are  relatively  common  disorders  and  can  be  divided  into  organ-specific  and  systemic  autoimmune  diseases  based  on  the  autoantigens  targeted  by  immune  cells.Although  the  underlying  etiologies  of  these  illnesses  are  still  elusive,  they  arise  in  the  context  of  a  break  in  the  immune  tolerance  to  self.The  mechanisms  for  abrogation  of  immune  self-tolerance  appear  to  be  multifactorial,  including  genetic  and  environmental,  that  lead  to  unregulated  immune  activation  against  self-antigens  and  subsequent  tissue  destruction.B  cells  and  T  cells  recognize  self-antigens  and  dominate  the  phenotype  of  the  patient  with  autoimmunity,  although  other  immune  components  including  antigen-presenting  cells  and  complement  are  involved  in  various  steps  from  initiation  of  the  autoimmune  response  to  tissue  destruction.