RT Book, Section
A1 Tharp, Michael D.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56073159
T1 Chapter 149. Mastocytosis
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56073159
RD 2024/04/25
AB |PrintMastocytosis  at  a  GlanceThe  hallmark  of  mastocytosis  is  a  pathologic  accumulation  of  mast  cells  in  tissues.Mastocytosis  occurs  at  any  age.The  skin  is  the  most  commonly  involved  organ  system.Cutaneous  findings  consist  of  hyperpigmented  macules,  papules  or  nodules,  or  a  diffuse  infiltration  of  the  dermis.Generally  benign  in  children.In  adults,  most  commonly  associated  with  a  somatic  activating  mutation  of  c-kit  (codons  816  and  560).Cutaneous  manifestations  may  occur  alone  or  in  association  with  systemic  disease.Related  features  may  be  flushing,  pruritus,  hypotension,  nausea,  dyspepsia,  and  diarrhea.Most  common  extracutaneous  tissues  involved  are  the  bone  marrow,  liver,  spleen,  and  lymph  nodes.May  be  associated  with  myeloproliferative  and  myelodysplastic  disorders.Classification  of  mastocytosis  is  critical  for  prognosis  and  treatment.