RT Book, Section
A1 Gelmetti, Carlo
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56072946
T1 Chapter 148. Non-Langerhans Cell Histiocytosis
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56072946
RD 2023/06/07
AB |PrintNonlangerhans  Cell  Histiocytosis  at  a  GlanceA  broad  group  of  disorders  characterized  by  the  proliferation  of  histiocytes  involving  cells  other  than  Langerhans  cells.Not  rare.  Most  cases  are  in  infants  and  run  a  benign,  self-healing  course  lasting  a  few  years.The  primary  histopathologic  feature  is  a  dense,  diffuse  infiltrate  that  is  less  epidermotropic  than  in  Langerhans  cell  histiocytosis  (LCH)  and  composed  of  occasionally  foamy  macrophages  intermingled  with  lymphocytes,  plasma  cells,  eosinophils,  and  sometimes  Touton  giant  cells.In  typical  cases,  histiocytes  are  CD68+  but  CD1a–  and  CD207–.Most  common  sites  of  involvement  are  the  head,  trunk,  and  skin  folds,  with  mucosal  lesions  rare.Systemic  manifestations  such  as  ocular  involvement,  diabetes  insipidus,  and  joint  and  visceral  impairment  are  rare  in  juvenile  xanthogranuloma,  the  most  common  type  of  non-Langerhans  cell  histiocytosis  (NLCH),  but  are  common  in  the  rarer  forms  of  NLCH.