RT Book, Section
A1 Darling, Thomas N.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56070051
T1 Chapter 140. Tuberous Sclerosis Complex
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56070051
RD 2024/04/23
AB |PrintTuberous  Sclerosis  Complex  at  a  GlanceAutosomal  dominant  syndrome  with  variable  expressivity.Manifested  by  hamartomatous  tumors  in  multiple  organs,  including  brain  (causing  seizures),  eyes,  heart,  kidneys,  lungs,  and  skin.Skin  lesions  occur  in  nearly  all  individuals  and  are  important  for  diagnosis.Skin  lesions  include  hypomelanotic  macules,  “confetti”  lesions,  facial  angiofibromas,  fibrous  facial  plaque,  shagreen  patch,  and  ungual  fibromas.Hypomelanotic  macules  appear  at  birth  or  shortly  thereafter  and  are  most  useful  in  early  diagnosis.Although  the  skin  lesions  are  benign,  they  may  require  treatment  due  to  symptoms  or  disfigurement.