RT Book, Section
A1 Lachmann, Helen J.
A1 Hawkins, Philip N.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56066820
T1 Chapter 133. Amyloidosis of the Skin
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56066820
RD 2024/04/19
AB |PrintAmyloidosis  and  the  Skin  at  a  GlanceIn  amyloidosis  normally  soluble  plasma  proteins  are  deposited  in  the  extracellular  space  in  an  abnormal  insoluble  fibrillar  form.Amyloid  deposition  is  remarkably  diverse  and  can  be  localized  or  systemic,  rapidly  lethal  or  incidental.Diagnosis  of  amyloidosis  relies  on  the  demonstration  of  pathognomonic  red–green  birefringence  when  biopsies  stained  with  Congo  red  are  viewed  under  cross-polarized  light.Management  relies  on  determining  the  type  (defined  by  the  precursor  protein)  and  discriminating  systemic  from  localized  forms.Treatment  of  systemic  disease  centers  on  reducing  the  production  of  the  fibril  precursor  protein  and  management  of  localized  disease  is  usually  surgical  or  symptomatic.